Zinc(II)-The Overlooked eminence Grise of Chloroquine's Fight against COVID-19?

Hecel, Aleksandra; Ostrowska, Malgorzata; Stokowa-Soltys, Kamila; Watly, Joanna; Dudek, Dorota; Miller, Adriana; Potocki, Slawomir; Matera-Witkiewicz, Agnieszka; Dominguez-Martin, Alicia; Kozlowski, Henryk; Rowinska-Zyrek, Magdalena

Publicación: PHARMACEUTICALS
2020
VL / 13 - BP / - EP /
abstract
Zn(II) is an inhibitor of SARS-CoV-2 ' s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores-this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics.

Access level

Green published, Gold