Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)

Obon-Santacana, Mireia; Romaguera, Dora; Gracia-Lavedan, Esther; Molinuevo, Amaia; Molina-Montes, Esther; Shivappa, Nitin; Hebert, James R.; Tardon, Adonina; Castano-Vinyals, Gemma; Moratalla, Ferran; Guino, Elisabet; Marcos-Gragera, Rafael; Azpiri, Mikel; Gil, Leire; Olmedo-Requena, Rocio; Lozano-Lorca, Macarena; Alguacil, Juan; Fernandez-Villa, Tania; Martin, Vicente; Molina, Antonio J.; Ederra, Maria; Moreno-Iribas, Conchi; Perez, Beatriz; Aragones, Nuria; Castello, Adela; Huerta, Jose Ma; Dierssen-Sotos, Trinidad; Gomez-Acebo, Ines; Molina-Barcelo, Ana; Pollan, Marina; Kogevinas, Manolis; Moreno, Victor; Amiano, Pilar

Publicación: NUTRIENTS
2019
VL / 11 - BP / - EP /
abstract
Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII (R)), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60-2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99-1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26-1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.

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Green published, Gold