Trabajos de Alvaro Pascual

Trabajos de Nombre

Pharmacology & Toxicology


  Listando 39 trabajos del autor/autora 38
Lista de trabajos en el área Pharmacology & Toxicology
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Article Do specific antimicrobial stewardship interventions have an impact on carbapenem resistance in Gram-negative bacilli? A multicentre quasi-experimental ecological study: time-trend analysis and characterization of carbapenemases Alvarez-Marin, Rocio; Lopez-Cerero, Lorena; Guerrero-Sanchez, Francisca; Palop-Borras, Begona; Dolores Rojo-Martin, Maria; Ruiz-Sancho, Andres; Herrero-Rodriguez, Carmen; Victoria Garcia, Maria; Maria Lazo-Torres, Ana; Lopez, Inmaculada; Martin-Hita, Lina; JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2021) DOI / 10.1093/jac/dkab073
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Article Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System Fernandez-Garcia, Laura; Fernandez-Cuenca, Felipe; Blasco, Lucia; Lopez-Rojas, Rafael; Ambroa, Anton; Lopez, Maria; Pascual, Alvaro; Bou, German; Tomas, Maria ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2018) DOI / 10.1128/aac.00250-18 Green published, Gold other
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Article Development and validation of the INCREMENT-ESBL predictive score for mortality in patients with bloodstream infections due to extendedspectrum- beta-lactamase-producing Enterobacteriaceae Raquel Palacios-Baena, Zaira; Gutierrez-Gutierrez, Belen; de Cueto, Marina; Viale, Pierluigi; Venditti, Mario; Hernandez-Torres, Alicia; Oliver, Antonio; Martinez-Martinez, Luis; Calbo, Esther; Pintado, Vicente; Gasch, Oriol; Almirante, Benito; Antonio Lep JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2017) DOI / 10.1093/jac/dkw513 Green published, Bronze
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Article Activity of cefiderocol against high-risk clones of multidrug-resistant Enterobacterales, Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia Delgado-Valverde, Mercedes; del Carmen Conejo, M.; Serrano, Lara; Fernandez-Cuenca, Felipe; Pascual, Alvaro JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2020) DOI / 10.1093/jac/dkaa117 Gold other, Green published
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Article Urinary Tract Conditions Affect Fosfomycin Activity against Escherichia coli Strains Harboring Chromosomal Mutations Involved in Fosfomycin Uptake Martin-Gutierrez, G.; Docobo-Perez, F.; Rodriguez-Beltran, J.; Rodriguez-Martinez, J. M.; Aznar, J.; Pascual, A.; Blazquez, J. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2018) DOI / 10.1128/aac.01899-17 Green published, Bronze
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Article Plasmidic qnr Genes Confer Clinical Resistance to Ciprofloxacin under Urinary Tract Physiological Conditions Martin-Gutierrez, Guillermo; Manuel Rodriguez-Martinez, Jose; Pascual, Alvaro; Rodriguez-Beltran, Jeronimo; Blazquez, Jesus ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2017) DOI / 10.1128/aac.02615-16 Bronze, Green published
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Article Enhanced Antibacterial Activity of Repurposed Mitomycin C and Imipenem in Combination with the Lytic Phage vB_KpnM-VAC13 against Clinical Isolates of Klebsiella pneumoniae Pacios, Olga; Fernandez-Garcia, Laura; Bleriot, Ines; Blasco, Lucia; Gonzalez-Bardanca, Monica; Lopez, Maria; Fernandez-Cuenca, Felipe; Oteo, Jesus; Pascual, Alvaro; Martinez-Martinez, Luis; Domingo-Calap, Pilar; Bou, German; Tomas, Maria ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2021) DOI / 10.1128/aac.00900-21
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Article Reporting antimicrobial susceptibilities and resistance phenotypes in Acinetobacter spp: a nationwide proficiency study Fernandez-Cuenca, Felipe; Tomas, Maria; Caballero-Moyano, Francisco-Javier; Bou, German; Pascual, Alvaro JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2018) DOI / 10.1093/jac/dkx464 Bronze
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Article Molecular insights into fosfomycin resistance in Escherichia coli Ballestero-Tellez, M.; Docobo-Perez, F.; Portillo-Calderon, I.; Rodriguez-Martinez, J. M.; Racero, L.; Ramos-Guelfo, M. S.; Blazquez, J.; Rodriguez-Bano, J.; Pascual, A. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2017) DOI / 10.1093/jac/dkw573 Bronze
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Article Susceptibility testing and detection of beta-lactam resistance mechanisms in Enterobacteriaceae: a multicentre national proficiency study Diez-Aguilar, Maria; Conejo, Maria-Carmen; Morosini, Maria-Isabel; Tormo Palop, Nuria; Gimeno, Concepcion; Canton, Rafael; Pascual, Alvaro INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 0924-8579 (2018) DOI / 10.1016/j.ijantimicag.2017.12.008
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Article Incidence and Risk Factors for Acquisition of Extended-Spectrum beta-Lactamase-Producing Enterobacteriaceae in Newborns in Seville, Spain: A Prospective Cohort Study Jesus Rodriguez-Revuelta, Maria; Lopez-Cerero, Lorena; Serrano, Lara; Luna-Lagares, Salud; Pascual, Alvaro; Rodriguez-Bano, Jesus INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 0924-8579 (2018) DOI / 10.1016/j.ijantimicag.2018.09.007
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Article Geographical variation in therapy for bloodstream infections due to multidrug-resistant Enterobacteriaceae: a post-hoc analysis of the INCREMENT study Harris, Patrick N. A.; Pezzani, M. Diletta; Gutierrez-Gutierrez, Belen; Viale, Pierluigi; Hsueh, Po-Ren; Ruiz-Garbajosa, Patricia; Venditti, Mario; Tumbarello, Mario; Navarro-Francisco, Carolina; Calbo, Esther; Akova, Murat; Giamarellou, Helen; Oliver, Ant INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 0924-8579 (2017) DOI / 10.1016/j.ijantimicag.2017.08.005 Green accepted
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Article MIC of amoxicillin/clavulanate according to CLSI and EUCAST: discrepancies and clinical impact in patients with bloodstream infections due to Enterobacteriaceae Delgado-Valverde, Mercedes; Valiente-Mendez, Adoracion; Torres, Eva; Almirante, Benito; Gomez-Zorrilla, Silvia; Borrell, Nuria; Isabel Aller-Garcia, Ana; Gurgui, Mercedes; Almela, Manel; Sanz, Mercedes; Bou, German; Martinez-Martinez, Luis; Canton, Rafael; JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2017) DOI / 10.1093/jac/dkw562 Bronze
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Article Cost-Effectiveness Analysis of Bezlotoxumab Added to Standard of Care Versus Standard of Care Alone for the Prevention of Recurrent Clostridium difficile Infection in High-Risk Patients in Spain Salavert, Miguel; Cobo, Javier; Pascual, Alvaro; Aragon, Belen; Maratia, Stefano; Jiang, Yiling; Aceituno, Susana; Grau, Santiago ADVANCES IN THERAPY 0741-238X (2018) DOI / 10.1007/s12325-018-0813-y Green published, Gold other
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Article Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes : more similarities than differences Alvarez-Marin, Rocio; Antonio Lepe, Jose; Gasch-Blasi, Oriol; Manuel Rodriguez-Martinez, Jose; Calvo-Montes, Jorge; Lara-Contreras, Rosario; Martin-Gandul, Cecilia; Tubau-Quintano, Fe; Eliecer Cano-Garcia, Maria; Rodriguez-Lopez, Fernando; Rodriguez-Bano, JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE 2213-7165 (2021) DOI / 10.1016/j.jgar.2021.04.008 Gold
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Article Mechanisms of Tolerance and Resistance to Chlorhexidine in Clinical Strains ofKlebsiella pneumoniaeProducers of Carbapenemase: Role of New Type II Toxin-Antitoxin System, PemIK Bleriot, Ines; Blasco, Lucia; Delgado-Valverde, Mercedes; Gual-de-Torrella, Ana; Ambroa, Anton; Fernandez-Garcia, Laura; Lopez, Maria; Oteo-Iglesias, Jesus; Wood, Thomas K.; Pascual, Alvaro; Bou, German; Fernandez-Cuenca, Felipe; Tomas, Maria TOXINS (2020) DOI / 10.3390/toxins12090566 Gold other, Green published
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Article High incidence of MDR and XDR Pseudomonas aeruginosa isolates obtained from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial Perez, Astrid; Gato, Eva; Perez-Llarena, Jose; Fernandez-Cuenca, Felipe; Jose Gude, Maria; Oviano, Marina; Eugenia Pachon, Maria; Garnacho, Jose; Gonzalez, Veronica; Pascual, Alvaro; Miguel Cisneros, Jose; Bou, German JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2019) DOI / 10.1093/jac/dkz030 Bronze
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Letter Quantitative and automated MALDI-TOF MS-based detection of the plasmid-mediated quinolone resistance determinant AAC(6 ')-Ib-cr in Enterobacteriaceae Oviano, Marina; Gomara, Marta; Jose Barba, Maria; Sparbier, Katrin; Pascual, Alvaro; Bou, German JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2017) DOI / 10.1093/jac/dkx218 Bronze
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Article Activity of ceftolozane/tazobactam against Pseudomonas aeruginosa and Enterobacterales isolates recovered from intensive care unit patients in Spain: The SUPERIOR multicentre study Garcia-Fernandez, Sergio; Garcia-Castillo, Maria; Bou, German; Calvo, Jorge; Cercenado, Emilia; Delgado, Mercedes; Pitart, Cristina; Mulet, Xavier; Tormo, Nuria; Lopez Mendoza, Diego; Diaz-Reganon, Jazmin; Canton, Rafael; Oliver, Antonio; Pascual, Alvaro; INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 0924-8579 (2019) DOI / 10.1016/j.ijantimicag.2019.02.004
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Article Contribution of hypermutation to fosfomycin heteroresistance in Escherichia coli Portillo-Calderon, Ines; Ortiz-Padilla, Miriam; Manuel Rodriguez-Martinez, Jose; de Gregorio-Iaria, Belen; Blazquez, Jesus; Rodriguez-Bano, Jesus; Pascual, Alvaro; Docobo-Perez, Fernando JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2020) DOI / 10.1093/jac/dkaa131
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Article In vitro activity of cefiderocol and comparators against isolates of Gram-negative bacterial pathogens from a range of infection sources: SIDERO-WT-2014-2018 studies in Spain Cercenado, Emilia; Cardenoso, Laura; Penin, Rocio; Longshaw, Christopher; Henriksen, Anne Santerre; Pascual, Alvaro JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE 2213-7165 (2021) DOI / 10.1016/j.jgar.2021.06.011 Gold
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Article Prevalence of ST131 Clone Producing Both ESBL CTX-M-15 and AAC(6)Ib-cr Among Ciprofloxacin-Resistant Escherichia coli Isolates from Yemen Alsharapy, Sameer Ahmed; Yanat, Betitera; Lopez-Cerero, Lorena; Nasher, Samar Saeed; Diaz-de-Alba, Paula; Pascual, Alvaro; Rodriguez-Martinez, Jose-Manuel; Touati, Abdelaziz MICROBIAL DRUG RESISTANCE 1076-6294 (2018) DOI / 10.1089/mdr.2018.0024
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Article OXA-48-Like-Producing Klebsiella pneumoniae in Southern Spain in 2014-2015 Machuca, Jesus; Lopez-Cerero, Lorena; Fernandez-Cuenca, Felipe; Mora-Navas, Laura; Mediavilla-Gradolph, Concepcion; Lopez-Rodriguez, Inmaculada; Pascual, Alvaro ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2019) DOI / 10.1128/aac.01396-18 Green published, Bronze
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Article Molecular Characterization of Fluoroquinolone-Resistant Haemophilus parainfluenzae Clinical Isolates in Spain Lopez-Hernandez, Inmaculada; Machuca, Jesus; Diaz de Alba, Paula; Sarvise, Carolina; Gomez, Frederic; Manuel Rodriguez-Martinez, Jose; Pascual, Alvaro MICROBIAL DRUG RESISTANCE 1076-6294 (2017) DOI / 10.1089/mdr.2016.0186
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Article Prevalence of Aminoglycoside-Modifying Enzymes in Escherichia coli and Klebsiella pneumoniae Producing Extended Spectrum -Lactamases Collected in Two Multicenter Studies in Spain Fernandez-Martinez, Marta; Ruiz del Castillo, Belen; Jesus Lecea-Cuello, Maria; Rodriguez-Bano, Jesus; Pascual, Alvaro; Martinez-Martinez, Luis MICROBIAL DRUG RESISTANCE 1076-6294 (2018) DOI / 10.1089/mdr.2017.0102 Green published
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Article Molecular topology: A new strategy for antimicrobial resistance control Zanni, Riccardo; Galvez-Llompart, Maria; Machuca, Jesus; Garcia-Domenech, Ramon; Recacha, Esther; Pascual, Alvaro; Manuel Rodriguez-Martinez, Jose; Galvez, Jorge EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 0223-5234 (2017) DOI / 10.1016/j.ejmech.2017.05.055
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Article Characterization of Plasmid-Mediated Quinolone Resistance Determinants in High-Level Quinolone-Resistant Enterobacteriaceae Isolates from the Community: First Report of qnrD Gene in Algeria Yanat, Betitera; Machuca, Jesus; Diaz-de-Alba, Paula; Mezhoud, Halima; Touati, Abdelaziz; Pascual, Alvaro; Rodriguez-Martinez, Jose-Manuel MICROBIAL DRUG RESISTANCE 1076-6294 (2017) DOI / 10.1089/mdr.2016.0031
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Article Reporting antimicrobial susceptibilities and resistance phenotypes in Staphylococcus spp.: a nationwide proficiency study Fernandez-Cuenca, Felipe; Lopez-Hernandez, Inmaculada; Cercenado, Emilia; Conejo, Carmen; Tormo, Nuria; Gimeno, Concha; Pascual, Alvaro JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2021) DOI / 10.1093/jac/dkab017
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Article Cytotoxic Effect Associated with Overexpression of QNR Proteins in Escherichia coli Machuca, Jesus; Diaz de Alba, Paula; Recacha, Esther; Pascual, Alvaro; Manuel Rodriguez-Martinez, Jose MICROBIAL DRUG RESISTANCE 1076-6294 (2017) DOI / 10.1089/mdr.2016.0245
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Article Occurrence of the Plasmid-Mediated Fluoroquinolone Resistance qepA1 Gene in Two Clonal Clinical Isolates of CTX-M-15-Producing Escherichia coli from Algeria Yanat, Betitera; Yahia, Radia Dali; Yazi, Leila; Machuca, Jesus; Diaz-de-Alba, Paula; Touati, Abdelaziz; Pascual, Alvaro; Rodriguez-Martinez, Jose-Manuel MICROBIAL DRUG RESISTANCE 1076-6294 (2017) DOI / 10.1089/mdr.2016.0135
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Article Bacteraemia due to non-ESBL-producing Escherichia coli O25b:H4 sequence type 131: insights into risk factors, clinical features and outcomes Morales-Barroso, Isabel; Lopez-Cerero, Lorena; Molina, Jose; Bellido, Mar; Dolores Navarro, Maria; Serrano, Lara; Gonzalez-Galan, Veronica; Praena, Julia; Pascual, Alvaro; Rodriguez-Bano, Jesus INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 0924-8579 (2017) DOI / 10.1016/j.ijantimicag.2016.12.013
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Article Intestinal colonization due to Escherichia coli ST131: risk factors and prevalence Morales Barroso, Isabel; Lopez-Cerero, Lorena; Dolores Navarro, Maria; Gutierrez-Gutierrez, Belen; Pascual, Alvaro; Rodriguez-Bano, Jesus ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL 2047-2994 (2018) DOI / 10.1186/s13756-018-0427-9 Gold DOAJ, Green published
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Article Suppression of the SOS response modifies spatiotemporal evolution, post-antibiotic effect, bacterial fitness and biofilm formation in quinolone-resistant Escherichia coli Recacha, E.; Machuca, J.; Diaz-Diaz, S.; Garcia-Duque, A.; Ramos-Guelfo, M.; Docobo-Perez, F.; Blazquez, J.; Pascual, A.; Rodriguez-Martinez, J. M. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2019) DOI / 10.1093/jac/dky407 Bronze
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Article Interplay among Different Fosfomycin Resistance Mechanisms in Klebsiella pneumoniae Ortiz-Padilla, M.; De Gregorio-Iaria, B.; Blazquez, J.; Rodriguez-Bano, J.; Pascual, A.; Rodriguez-Martinez, J. M.; Docobo-Perez, F. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2021) DOI / 10.1128/aac.01911-20
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Article Extended-spectrum beta-lactamase-producing Enterobacteriaceae from animal origin and wastewater in Tunisia: first detection of O25b-B2(3)-CTX-M-27-ST131 Escherichia coli and CTX-M-15/OXA-204-producing Citrobacter freundii from wastewater Sghaier, Senda; Abbassi, Mohamed Salah; Pascual, Alvaro; Serrano, Lara; Diaz-de-Alba, Paula; Ben Said, Meriam; Hassen, Bilel; Ibrahim, Chourouk; Hassen, Abdennaceur; Lopez-Cerero, Lorena JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE 2213-7165 (2019) DOI / 10.1016/j.jgar.2019.01.002
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Article Role of low-level quinolone resistance in generating tolerance in Escherichia coli under therapeutic concentrations of ciprofloxacin Ortiz-Padilla, M.; Diaz-Diaz, S.; Machuca, J.; Tejada-Gonzalez, A.; Recacha, E.; Docobo-Perez, F.; Pascual, A.; Rodriguez-Martinez, J. M. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2020) DOI / 10.1093/jac/dkaa151
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Article Activity of Fosfomycin and Amikacin against Fosfomycin-Heteroresistant Escherichia coli Strains in a Hollow-Fiber Infection Model Ortiz-Padilla, M.; De Gregorio-Iaria, B.; Blazquez, J.; Rodriguez-Bano, J.; Rodriguez-Martinez, J. M.; Pascual, A.; Docobo-Perez, F. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 0066-4804 (2021) DOI / 10.1128/aac.02213-20 Green published
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Article Effect of RecA inactivation on quinolone susceptibility and the evolution of resistance in clinical isolates of Escherichia coli Machuca, J.; Recacha, E.; Gallego-Mesa, B.; Diaz-Diaz, S.; Rojas-Granado, G.; Garcia-Duque, A.; Docobo-Perez, F.; Blazquez, J.; Rodriguez-Rojas, A.; Pascual, A.; Rodriguez-Martinez, J. M. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 0305-7453 (2021) DOI / 10.1093/jac/dkaa448
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Article Population Pharmacokinetics of Piperacillin in Non-Critically Ill Patients with Bacteremia Caused by Enterobacteriaceae Merino-Bohorquez, Vicente; Docobo-Perez, Fernando; Valiente-Mendez, Adoracion; Delgado-Valverde, Mercedes; Camean, Manuel; Hope, William W.; Pascual, Alvaro; Rodriguez-Bano, Jesus ANTIBIOTICS-BASEL 2079-6382 (2021) DOI / 10.3390/antibiotics10040348 Gold DOAJ, Green published