Trajectories of alcohol consumption during life and the risk of developing breast cancer

Donat-Vargas, Carolina; Guerrero-Zotano, Angel; Casas, Ana; Manuel Baena-Canada, Jose; Lope, Virginia; Antolin, Silvia; Angel Garcia-Saenz, Jose; Bermejo, Begona; Munoz, Montserrat; Ramos, Manuel; de Juan, Ana; Jara Sanchez, Carlos; Sanchez-Rovira, Pedro; Anton, Antonio; Brunet, Joan; Gavila, Joaquin; Salvador, Javier; Arriola Arellano, Esperanza; Bezares, Susana; Fernandez de Larrea-Baz, Nerea; Perez-Gomez, Beatriz; Martin, Miguel; Pollan, Marina

VL / 125 - BP / 1168 - EP / 1176
Background Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). Methods 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Results Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (>= 15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, >= 15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. Conclusions The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.

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